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c/cagrilintide·submitted 11 months ago by u/freya_baptista

co-agonism — my 6-week log, condensed into one table

Discussionbranch of 10 comments

Posting this because I searched for it and got nothing useful. Setup: 0.25mg, week 28, constipation present but not ruining anything. I changed exactly one variable — REDEFINE — and tracked it for 21 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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10 comments, started 11 months ago
u/noor_vermeulen320 points·11 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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[removed]242 points·11 months ago

[removed by moderator]

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u/ferran_mensah122 points·11 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/freya_baptista73 points·11 months ago

not approved anywhere, keep posts descriptive, not instructional

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u/hplc_hobbyistruns their own column18 points·11 months ago

This is correct. The co-agonism is real.

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u/lipid_panel_larrybloodwork46 points·11 months ago

research use only, no human protocols in posts

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u/helga_vermeulen149 points·11 months ago

[removed by moderator]

Yes, exactly this, and it is the bit that took me 65 weeks to accept.

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u/zeynep_zielinski71 points·11 months ago

Yeah, amylin is doing different work than GLP-1.

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u/zaid_balogun254 points·11 months ago

Rodent or human data?

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u/controversial_only131 points·11 months ago

amylin is not a GLP-1, posts conflating them get corrected

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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