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c/cagrilintide·posted 11 months ago by u/pavel_halvorsen

what would you tell week-1 you about REDEFINE

Discussion Sourced ×5 Slow Clap ×1

Confession thread, sort of.

I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 12 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 49 reads it before doing the same thing.

1,317 up / 115 down92% upvoted41 commentsid 1bazau28 Aug 2025

41 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/aa_analysis_andy223 points·11 months ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/incretin_ivypharmacology167 points·11 months ago

research use only, no human protocols in posts

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u/lucia_bruun69 points·11 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/amylin_amyamylin48 points·11 months ago

tendon and co-agonism literature in rodents is interesting

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u/liv_dumitru135 points·11 months ago·edited

Strongly agree. REDEFINE is phase 3, not final.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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