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c/cagrilintide·submitted 9 months ago by u/crosspost_bot_no

[Results] 42 weeks, 25kg, and co-agonism was the hard part

Cautionbranch of 6 comments

I have had 21 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 18 days on nominally the same lane, which matters more in summer than in February. The independent number came back 96.8% against a claimed…

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6 comments, started 9 months ago
u/yannick_salinas24 points·9 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/tomas_kimani28 points·9 months ago

Mechanistically the bit that matters is satiety. It explains most of the early profile and a decent chunk of the outcome.

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u/andres_dahlberg23 points·9 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/zeynep_weiss12 points·9 months ago

the amylin agonist pool is small, community is amylin

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u/emeka_chowdhury14 points·9 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/sulphur_burps_sue4 points·9 months ago·edited

Strongly agree. REDEFINE is phase 20, not final.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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