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c/cagrilintide·submitted 7 months ago by u/lane_map_larry

week 61 check-in — 41kg down, nausea manageable, one thing confusing me

Discussionbranch of 10 comments

Confession thread, sort of. I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I…

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10 comments, started 7 months ago
u/tomas_kimani36 points·7 months ago

the amylin agonist pool is small, community is amylin

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u/forest_plot_fionastats43 points·7 months ago

the amylin agonist pool is small, community is amylin

Disagree on that part. 98.7% and 98.7% on the same vial is normal.

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u/lukas_vermeulen15 points·7 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/nadia_fonseca25 points·7 months ago

the amylin agonist pool is small, community is satiety

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u/declared_value_dv16 points·7 months ago

This is correct. The co-agonism is real.

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u/lane_map_larryOPlogistics12 points·7 months ago

REDEFINE which arm?

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u/solene_abubakar12 points·7 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/milos_vestergaard17 points·7 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/ines_ekstrom12 points·7 months ago

REDEFINE readouts are phase 7 data

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u/rania_marchand9 points·7 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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