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c/cagrilintide·posted 3 months ago by u/ms_fragmenter

reading cagrilintide threads from 2024 and half of it aged badly

Caution

Posting this because I searched for it and got nothing useful.

Setup: 1.0mg, week 16, injection-site soreness present but not ruining anything. I changed exactly one variable — satiety — and tracked it for 10 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

318 up / 104 down75% upvoted18 commentsid fe2p2q19 Apr 2026

18 comments

15 in this archive, depth 6

best — the order this archive was captured in

u/iman_castellanos0 points·3 months ago

tendon and CagriSema literature in rodents is interesting

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[deleted]1 point·3 months ago

[deleted]

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u/ms_fragmenter1 point·3 months ago

Slight fix: the number was 98.1, not 98.0. Decimal point, but a fairly consequential one.

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u/amylin_amyamylin1 point·3 months ago

Slight fix: the number was 98.1, not 98.0.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/slow_logbook_notes301 point·3 months ago

CagriSema is a fixed combo in trials, not user-mixed

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u/hana_pereira1 point·3 months ago

Not to be pedantic but co-agonism and REDEFINE are being used interchangeably and they are not interchangeable in real life.

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u/zaid_balogun1 point·3 months ago

research use only, no human protocols in posts

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u/chidi_yilmaz1 point·3 months ago

REDEFINE which arm?

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u/solene_abubakar1 point·3 months ago·edited

not approved anywhere, keep posts descriptive, not instructional

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u/lane_map_larrylogistics1 point·3 months ago

Not to be pedantic but amylin and CagriSema are being used interchangeably and they are not interchangeable in real life.

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u/zeynep_weiss1 point·3 months ago

long-acting amylin is CagriSema, different satiety profile

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u/crosspost_bot_no1 point·3 months ago

Strongly agree. REDEFINE is phase 13, not final.

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u/sulphur_burps_sue1 point·3 months ago

Not to be pedantic but CagriSema and amylin are being used interchangeably and they are not interchangeable in real life.

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u/zeynep_duarte1 point·3 months ago

amylin is not a GLP-1, posts conflating them get corrected

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u/slow_logbook_notes301 point·3 months ago

Strongly agree.

Adding to this: amylin is doing more work than the comment implies.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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  1. Amylin is not a GLP-1. Posts conflating them get corrected.
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