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c/cagrilintide·submitted 3 months ago by u/protein_first_p

[PSA] REDEFINE is not what most of this community thinks it is

Cautionbranch of 4 comments

Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 14 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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4 comments, started 3 months ago
u/amylin_amyMOD14 points·3 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/b12_baseline11 points·3 months ago

This is an urgent-care question wearing a forum question's clothes.

Adding to this: amylin is doing more work than the comment implies.

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u/protein_first_pOPnutrition8 points·3 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does CagriSema.

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u/titration_marshalmod · c/semaglutide3 points·3 months ago

Strongly agree. REDEFINE is phase 17, not final.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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