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c/cagrilintide·posted 2 months ago by u/wrong_network_w

Denmark: co-agonism, and what it actually costs here

Question

Been lurking in c/cryptopay for about 19 months and finally have something worth posting.

Short version: week 6, 1.0mg, and REDEFINE is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 9 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 95.

0 up / 0 down42% upvoted9 commentsid g81i5n16 May 2026

9 comments

9 in this archive, depth 5

best — the order this archive was captured in

u/hedda_aguirre2 points·2 months ago·edited

the mechanism is different, the side effect profile reflects it

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u/milos_vestergaard1 point·2 months ago

Strongly agree. REDEFINE is phase 23, not final.

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u/protein_first_pnutrition1 point·2 months ago

REDEFINE readouts are phase 22 data

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u/viktor_erdogan1 point·2 months ago

Yeah, amylin is doing different work than GLP-1.

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u/wrong_network_wOP1 point·2 months ago

Rodent or human data?

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u/blunt_coldbox1 point·2 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/wrong_network_wOP1 point·2 months ago

the co-agonism question is real and interesting

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u/lipid_panel_larrybloodwork1 point·2 months ago

research use only, no human protocols in posts

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u/protein_first_pnutrition1 point·2 months ago

Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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