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c/cagrilintide·submitted 1 months ago by u/mateusz_adebayo

[Question] Sweden — has anyone got a straight answer on amylin

Questionbranch of 11 comments

I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 32 days on nominally the same lane, which matters more in summer than in February. The independent number came back 93.7% against a claimed…

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11 comments, started 1 months ago
u/ravi_sandvik12 points·1 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/noor_hovland6 points·1 months ago

The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.

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u/amara_kuipers8 points·1 months ago

The satiety on amylin analogs is described as physically different.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[deleted]5 points·1 months ago

[deleted]

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u/zaid_grimaldi4 points·1 months ago·edited

REDEFINE readouts are phase 19 data

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u/emeka_chowdhury2 points·1 months ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/amylin_amyMOD4 points·1 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/emeka_beaulieu1 point·1 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/noor_ivaturi2 points·1 months ago

amylin receptor distribution is different from GLP-1

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u/solene_abubakar1 point·1 months ago

This is correct. The co-agonism is real.

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u/micro_bump_mick1 point·1 months ago

tendon and CagriSema literature in rodents is interesting

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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