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c/cagrilintide·submitted 27 days ago by u/sulphur_burps_sue

co-agonism — my 4-week log, condensed into one table

Questionbranch of 6 comments

Been lurking in c/orforglipron for about 9 months and finally have something worth posting. Short version: week 4, 2.5mg, and amylin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 19 threads, and the answers split roughly down the middle. What I actually want to know is…

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6 comments, started 25 days ago
u/titration_marshalmod · c/semaglutide4 points·25 days ago

Yeah, amylin is doing different work than GLP-1.

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[deleted]3 points·25 days ago

[deleted]

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u/ilias_kaufmann1 point·25 days ago

Yeah, amylin is doing different work than GLP-1.

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u/rafael_krastev2 points·25 days ago

This is correct. The co-agonism is real.

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u/zaid_balogun2 points·25 days ago

tendon and CagriSema literature in rodents is interesting

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u/erez_perrin2 points·25 days ago·edited

Yeah, amylin is doing different work than GLP-1.

Adding to this: amylin is doing more work than the comment implies.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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