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c/coldchain·submitted 11 months ago by u/marta_ilunga

reading stability threads from 2024 and half of it aged badly

Databranch of 9 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that stability is important. I believe it, but I have never seen anyone show why, and when I search I get 3 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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9 comments, started 11 months ago
u/andres_restrepo133 points·11 months ago

Crossposting this to c/tapering because the people who need it are not reading this community.

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u/bence_ibarra76 points·11 months ago

Crossposting this to c/tapering because the people who need it are not reading this community.

Adding to this: ice pack is doing more work than the comment implies.

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u/creatine_and_cardio21 points·11 months ago

Small correction: the trial was 22 weeks, not 8. Does not change your point but people will quote it.

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u/marta_ilungaOP11 points·11 months ago

Small correction: the trial was 22 weeks, not 8.

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/andres_restrepo0 points·11 months ago

customs clearance often breaks the cold chain, factor that in

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u/hamza_weiss34 points·11 months ago·edited

stability after excursion is not zero, it is dose-dependent

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u/transit_variance27 points·11 months ago

Disagree. What you are describing is consistent with lyophilised, not with what you concluded.

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u/amara_dziedzic10 points·11 months ago

Yeah, data logger is the only acceptable proof.

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u/tomas_lokken9 points·11 months ago

stability after excursion is not zero, it is dose-dependent

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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