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411
c/compounding·posted 7 months ago by u/runa_grimaldi

[Discussion] we are measuring 503A at the wrong time and calling it noise

Discussion Receipts ×5

Trying to settle this properly because the thread from last year went in circles.

The claim: API source matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything.

What would actually settle it is 31 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

551 up / 140 down80% upvoted27 commentsid 1ot29n17 Dec 2025

27 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/teodor_duarte94 points·7 months ago

This is correct. The shortage list does expire and the rules change.

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u/chidi_demir-26 points·7 months ago

Did they tell you their API source or dodge the question?

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u/eu_apotheke_a1 point·7 months ago

the the UK situation is different from the US, different regulations

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u/runa_grimaldiOP1 point·7 months ago

regulatory claims need a citation to the actual rule, not interpretation

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u/emil_okwuosa1 point·7 months ago

state board rules differ, say which state

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[removed]1 point·7 months ago

[removed by moderator]

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u/burned_once_twice1 point·7 months ago

regulatory claims need a citation to the actual rule, not interpretation

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/runa_grimaldiOP1 point·7 months ago

Slight fix: the number was 95.1, not 94.2. Decimal point, but a fairly consequential one.

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u/honest_syringe56 points·7 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/vikram_mbeki46 points·7 months ago
the VendorInvestigate number or it did not happen
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u/rohan_steiner15 points·7 months ago

Not convinced. The evidence does not support that reading.

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u/camila_mensa10 points·7 months ago

no pharmacy referral codes, naming is fine, recruiting is not

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u/prior_auth_painMOD34 points·7 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/neha_krastev20 points·7 months ago

the 503A/503B distinction is load-bearing, do not blur it

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u/yannick_petrov17 points·7 months ago

Did they tell you their API source or dodge the question?

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u/hydration_hank5 points·7 months ago

Did they tell you their API source or dodge the question?

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/vikram_mbeki2 points·7 months ago

Not to be pedantic but 503B and compounding are being used interchangeably and they are not interchangeable in real life.

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u/step_count_stan1 point·7 months ago

shortage list status is telehealth, check the actual list

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u/hydration_hank22 points·7 months ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/vikram_mbeki6 points·7 months ago

Yeah, 503A and 503B are different regulatory animals.

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u/medutest_mel19 points·7 months ago

the the UK situation is different from the US, different regulations

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u/prior_auth_painappeals6 points·7 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/camila_mensa15 points·7 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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c/compounding rules
  1. Regulatory claims need a citation to the actual rule, notice or docket.
  2. No pharmacy referral codes. Naming a pharmacy is fine; recruiting for it is not.
  3. API source questions are on-topic and pharmacies dodging them is newsworthy.
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  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
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