GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
1.6k

[Results] 12 weeks, 25kg, and FFMI was the hard part

Results Cold Box ×8 The Quiet One ×3

Posting this because I searched for it and got nothing useful.

Setup: 0.25mg, week 95, sulphur burps present but not ruining anything. I changed exactly one variable — sarcopenia — and tracked it for 4 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

12,974 up / 11,332 down53% upvoted34 commentsid 5p06kq13 Jan 2025

34 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/protein_first_pnutrition241 points·1 year ago

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

replysharereportpermalink
u/mariam_cabrera149 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

replysharereportpermalink
u/lift_heavy_thingsMOD76 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

replysharereportpermalink
u/pavel_kravchenko51 points·1 year ago

Retitled to remove editorialising.

Yes, exactly this, and it is the bit that took me 54 weeks to accept.

replysharereportpermalink
u/meera_oyelaran14 points·1 year ago

DEXA is the real measurement

replysharereportpermalink
u/prior_auth_painappeals-24 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

replysharereportpermalink
u/erez_yilmaz12 points·1 year ago

bathroom BIA scales are not a method

replysharereportpermalink
u/cold_chromatogram_onlyOP48 points·1 year ago

Came off after 64 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

replysharereportpermalink
u/nl_verzekering34 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

replysharereportpermalink
u/nikhil_asante49 points·1 year ago

resistance training is sarcopenia not optional

replysharereportpermalink
u/cold_chromatogram_onlyOP0 points·1 year ago

Sweden here. Waited 21 months on a list, gave up, went private, and the total cost was roughly what I expected.

replysharereportpermalink
u/ferran_dahlberg0 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

replysharereportpermalink
u/liv_dumitru1 point·1 year ago

protein resistance training, not "lots"

replysharereportpermalink
u/sanne_novak92 points·1 year ago

Half-life is about 168 hours, so steady state lands around week 21–5. Practical consequence: what you feel in week 1 is not what that dose does.

replysharereportpermalink
u/formulary_fighterappeals43 points·1 year ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

replysharereportpermalink
u/aksel_kjaer34 points·1 year ago·edited

DEXA twice yearly is the pattern

replysharereportpermalink
u/joaquin_trevino27 points·1 year ago

bathroom BIA scales are not a method

replysharereportpermalink
u/milos_vestergaard23 points·1 year ago

protein targets in g/kg

replysharereportpermalink
u/dario_stanescu41 points·1 year ago

rapid loss plus no protein equals muscle loss

replysharereportpermalink
u/ferran_krastev32 points·1 year ago·edited

Yeah, protein matters on rapid loss.

replysharereportpermalink
[removed]30 points·1 year ago

[removed by moderator]

replysharereportpermalink
u/usp_appendixcompendial29 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

replysharereportpermalink
u/janek_ferrari11 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points.

Yes, exactly this, and it is the bit that took me 69 weeks to accept.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/glp1muscle

Lean-mass retention during rapid weight loss: protein targets, resistance-training minimums, DEXA and BIA measurement reality, FFMI tracking, and the sarcopenia question that nobody funded a proper trial for.

30kmembers
62submissions
Jun 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/glp1muscle rules
  1. Body-composition claims need a method. Bathroom BIA scales are not a method.
  2. Protein targets in g/kg, not "lots".
  3. No supplement selling, no coaching solicitation.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.