[Lab] 21th independent test on QSC, and the trend is the interesting part
gastric emptying. That is the whole post, but I will justify it.
Everything else people worry about in c/survodutide is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort gastric emptying out first, and almost nobody does.
I say this having got it wrong for 16 months. My fasting insulin was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Respectfully this is a sample of one presented as a finding.
the 6-day half-life means week 6 is still ramp-up pharmacokinetically
That is net peptide content, not purity. Different number, different meaning.
glucagon-receptor contribution is half-life for dual and triple agonism
Respectfully this is a sample of one presented as a finding.
Adding to this: mechanism is doing more work than the comment implies.
Strongly agree. Central appetite is real but people overstate it.
glucagon-receptor contribution is pharmacology for dual and triple agonism
amylin is not GLP-1, posts conflating them get corrected
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.
do not extrapolate rodent data to human dosing without saying so
do not extrapolate rodent data to human dosing without saying so
Yes, exactly this, and it is the bit that took me 7 weeks to accept.
rodent half-life tells you what to investigate, not what to expect in humans
[removed by moderator]
Sceptical. If this were true we would see it reflected in the data and we do not.
This is correct. Rodent data is investigational, not predictive.
Stomach physiology changed when I moved up to 12.5mg. Gastric emptying lag is the whole story.
Mechanistically the bit that matters is pharmacology. It explains most of the early profile and a decent chunk of the outcome.
- 1The evidence standard in c/vendorvetting gets called too strict about once a…9 comments in this branch · started by u/wholesome_lurker
- 2Respectfully this is a sample of one presented as a finding.5 comments in this branch · started by u/enzo_danquah