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Single comment threadYou are looking at one branch of [Discussion] can we stop arguing about mechanism until somebody posts a number — 53 comments in the full submission. View in context.
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c/glp1science·submitted 10 months ago by u/aa_analysis_andy

[Discussion] can we stop arguing about mechanism until somebody posts a number

Discussionbranch of 13 comments

I have had 3 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 22 days on nominally the same lane, which matters more in summer than in February. The independent number came back 97.9% against a claimed…

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13 comments, started 10 months ago
u/second_week_sceptic115 points·10 months ago

rodent receptor tells you what to investigate, not what to expect in humans

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u/farid_kuipers79 points·10 months ago

incretin physiology is mechanism, the mechanism layer

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u/santiago_rasmussen31 points·10 months ago

This is correct. Rodent data is investigational, not predictive.

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u/sig_figs_sammod · analytical94 points·10 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/camila_kowalski61 points·10 months ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/saskia_lokken20 points·10 months ago·edited

glucagon-receptor contribution is gastric emptying for dual and triple agonism

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u/camila_mensa37 points·10 months ago

Which paper are you quoting?

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u/rohan_steiner11 points·10 months ago·edited

Which paper are you quoting?

Adding to this: gastric emptying is doing more work than the comment implies.

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u/emil_agyeman20 points·10 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/anders_kuusela39 points·10 months ago

Not convinced. The evidence does not support that reading.

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u/aleksi_lehtinen32 points·10 months ago·edited

cite the paper: journal, year, first author, links optional

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u/mod_ambulatoryadmin27 points·10 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/signe_boateng19 points·10 months ago

Where does the half-life data actually come from?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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