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156
c/glp1science·posted 2 months ago by u/gastric_emptying_g

help me understand appetite, I have read the wiki twice

Question

Posting this because I searched for it and got nothing useful.

Setup: 15mg, week 71, sulphur burps present but not ruining anything. I changed exactly one variable — gastric emptying — and tracked it for 23 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

159 up / 3 down98% upvoted21 commentsid zbz7ga18 May 2026

21 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/anya_salgado-21 points·2 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/camila_kowalski1 point·2 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/gastric_emptying_gMOD15 points·2 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/karma_irrelevant10 points·2 months ago

Stomach physiology changed when I moved up to 2.5mg. Gastric emptying lag is the whole story.

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u/split_dose_sceptic5 points·2 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/aleksi_lehtinen4 points·2 months ago

Yeah, the incretin mechanism is doing the work here.

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u/brigade_detector4 points·2 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/georgi_chowdhury1 point·2 months ago

Not convinced. The evidence does not support that reading.

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u/noor_hovland1 point·2 months ago

receptor distribution matters, GLP-1 is not everywhere

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u/whois_wanda1 point·2 months ago

receptor distribution matters, GLP-1 is not everywhere

Adding to this: gastric emptying is doing more work than the comment implies.

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u/milan_mensah3 points·2 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/annika_fonseca1 point·2 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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