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c/glp1women·submitted 4 months ago by u/dose_creep_dan

unpopular opinion: PCOS is massively overrated

Cautionbranch of 8 comments

Genuinely asking, not being difficult. Everyone in c/orforglipron repeats that insulin resistance is important. I believe it, but I have never seen anyone show why, and when I search I get 19 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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8 comments, started 3 months ago
u/aleksi_eriksen15 points·3 months ago

Yeah, fertility is under-researched.

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u/santiago_marchetti13 points·3 months ago

I am going to push back on this slightly.

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u/sulphur_burps_sue19 points·3 months ago

hormonal contraception interactions are speculative

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u/micro_bump_mick9 points·3 months ago

hormonal contraception interactions are speculative

Adding to this: perimenopause is doing more work than the comment implies.

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u/ewan_zielinski8 points·3 months ago

Small correction: the trial was 20 weeks, not 22. Does not change your point but people will quote it.

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u/zaid_grimaldi5 points·3 months ago·edited

Stalled for 17 weeks, changed nothing, and it started moving again on week 2.

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u/tared_twice12 points·3 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/wholesome_lurker8 points·3 months ago

cycle changes are real and under-researched

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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