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c/glp1women·posted 4 months ago by u/dose_creep_dan

unpopular opinion: PCOS is massively overrated

Caution

Genuinely asking, not being difficult.

Everyone in c/orforglipron repeats that insulin resistance is important. I believe it, but I have never seen anyone show why, and when I search I get 19 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

185 up / 53 down78% upvoted20 commentsid 26h7bq30 Mar 2026

20 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/honest_syringe24 points·4 months ago

What are you comparing it against though?

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[deleted]17 points·4 months ago

[deleted]

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u/santiago_marchetti11 points·3 months ago

PCOS and insulin resistance

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u/lipid_panel_larrybloodwork-9 points·3 months ago

What was the batch number and which service?

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u/joaquin_trevino7 points·3 months ago

Strongly agree. Cycle changes are documented.

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u/wholesome_lurker21 points·4 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/nnt_nate7 points·3 months ago

Respectfully this is a sample of one presented as a finding.

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u/reads_the_wiki5 points·3 months ago

the insulin resistance question is under-powered in trials

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u/sanne_novak1 point·3 months ago

Not to be pedantic but contraception and fertility are being used interchangeably and they are not interchangeable in real life.

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u/aleksi_eriksen15 points·3 months ago

Yeah, fertility is under-researched.

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u/santiago_marchetti13 points·3 months ago

I am going to push back on this slightly.

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u/sulphur_burps_sue19 points·3 months ago

hormonal contraception interactions are speculative

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u/micro_bump_mick9 points·3 months ago

hormonal contraception interactions are speculative

Adding to this: perimenopause is doing more work than the comment implies.

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u/ewan_zielinski8 points·3 months ago

Small correction: the trial was 20 weeks, not 22. Does not change your point but people will quote it.

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u/zaid_grimaldi5 points·3 months ago·edited

Stalled for 17 weeks, changed nothing, and it started moving again on week 2.

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u/tared_twice12 points·3 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/wholesome_lurker8 points·3 months ago

cycle changes are real and under-researched

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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