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c/orforglipron·posted 1 months ago by u/joaquin_trevino

[Discussion] we are measuring small molecule at the wrong time and calling it noise

Discussion

Trying to settle this properly because the thread from last year went in circles.

The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 7 months without either producing anything.

What would actually settle it is 37 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

74 up / 98 down43% upvoted13 commentsid 11u3du22 Jun 2026

13 comments

13 in this archive, depth 5

best — the order this archive was captured in

u/declared_value_dv9 points·1 months ago

Yeah, small molecule changes the whole game.

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u/incretin_ivyMOD5 points·1 months ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/neha_mwangi1 point·1 months ago

small molecule purity is different testing than peptides

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u/trialwatch_theotrial nerd-20 points·1 months ago

This is correct. ATTAIN data is phase 13.

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u/lukas_delgado6 points·1 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/lukas_delgado1 point·1 months ago

the sulphur burps profile is speculative at this stage

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u/dario_boateng5 points·1 months ago

Yeah, small molecule changes the whole game.

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u/reship_roulette2 points·1 months ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/quiet_moderatormod1 point·1 months ago·edited

phase 6 data is interesting, phase 14 will tell the real story

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u/kenji_kimani1 point·1 months ago·edited

phase 16 data is interesting, phase 27 will tell the real story

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u/flair_enthusiast1 point·1 months ago

What was the batch number and which service?

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u/anders_karlsen4 points·1 months ago

Second this question. I have wondered about small molecule for 3 months and never seen a straight answer.

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u/honest_syringe_maybe1 point·1 months ago

Yeah, small molecule changes the whole game.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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