GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
-79
c/orforglipron·posted 1 months ago by u/certified_reference

is it normal to get constipation at week 64

Trial Data

Confession thread, sort of.

I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have sulphur burps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 50 reads it before doing the same thing.

1,972 up / 2,051 down50% upvoted12 commentsid 12o26x17 Jun 2026

12 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/kenji_laurent14 points·1 months ago
nobody says this and everybody needs to hear it
replysharereportpermalink
u/ayesha_erdogan9 points·1 months ago

This is correct. ATTAIN data is phase 20.

replysharereportpermalink
u/certified_referenceOPQC-26 points·1 months ago

The early fullness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

replysharereportpermalink
[removed]1 point·1 months ago

[removed by moderator]

replysharereportpermalink
load more comments (1) →
u/fabio_lehtinen6 points·1 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

replysharereportpermalink
u/certified_referenceOPQC3 points·1 months ago

small molecule, not a peptide, purity discussion is different

replysharereportpermalink
u/trialwatch_theoMOD4 points·1 months ago

Retitled to remove editorialising. Put the evidence in the body.

replysharereportpermalink
u/ines_lindqvist6 points·1 months ago·edited

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

replysharereportpermalink
u/kenji_kimani3 points·1 months ago·edited

Yeah, small molecule changes the whole game.

replysharereportpermalink
u/gustav_solberg2 points·1 months ago

Stalled for 10 weeks, changed nothing, and it started moving again on week 57.

replysharereportpermalink
u/rasmus_petrescu3 points·1 months ago

Disagree. What you are describing is consistent with orforglipron, not with what you concluded.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

21kmembers
62submissions
Feb 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/orforglipron rules
  1. Small molecule, not a peptide. Purity discussion here is a different problem.
  2. Cite ATTAIN/ACHIEVE arms specifically when quoting numbers.
  3. Availability speculation must be flaired Speculation.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.