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c/orforglipron·submitted 22 days ago by u/neha_mwangi

[Discussion] oral GLP-1 is doing more work than we give it credit for

Discussionbranch of 5 comments

Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 49, constipation present but not ruining anything. I changed exactly one variable — non-peptide — and tracked it for 11 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So…

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5 comments, started 22 days ago
u/emil_agyeman32 points·22 days ago

the absorption problem is solved by non-peptide structure

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[deleted]23 points·22 days ago

[deleted]

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u/emil_agyeman10 points·22 days ago

This is correct. ATTAIN data is phase 2.

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u/camila_vasquez4 points·21 days ago·edited

Did anything else change in the same window?

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u/neha_mwangiOP18 points·22 days ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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