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c/orforglipron·posted 4 months ago by u/rasmus_petrescu

why does nobody talk about non-peptide

Speculation Receipts ×9

Confession thread, sort of.

I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 18 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 61 reads it before doing the same thing.

914 up / 155 down85% upvoted33 commentsid xxzhn910 Mar 2026

33 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/viktor_laurent168 points·4 months ago·edited

ATTAIN and ACHIEVE are phase 20 trials

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u/erez_yilmaz39 points·4 months ago

Yeah, small molecule changes the whole game.

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u/piotr_bruun101 points·4 months ago

Strongly agree. The supply impact would be huge.

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u/dario_boateng64 points·4 months ago

What are you comparing it against though?

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u/rasmus_petrescuOP36 points·4 months ago

the supply conversation changes if this approves

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[removed]25 points·4 months ago

[removed by moderator]

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u/rasmus_petrescuOP26 points·4 months ago

availability speculation must be flaired Speculation

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u/purity_pedantanalytical62 points·4 months ago

no cold chain means ATTAIN, if approved

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u/gustav_solberg22 points·4 months ago

the absorption problem is solved by non-peptide structure

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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