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c/reconstitution·submitted 2 months ago by u/emil_zamora

dead space vs reconstitution — genuinely asking which matters more

PSAbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/cagrilintide repeats that dead space is important. I believe it, but I have never seen anyone show why, and when I search I get 18 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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6 comments, started 2 months ago
u/julia_erdogan131 points·2 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/vito_beaulieu-23 points·2 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/katrin_marchetti1 point·2 months ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/marisol_frisk43 points·2 months ago·edited

This is correct. 3mL versus 8mL is the common mistake.

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u/runa_cabrera36 points·2 months ago

i am begging people to write down the concentration

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u/karl_fischer_kev13 points·2 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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