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c/reconstitution·posted 4 months ago by u/ines_ekstrom

[Question] mg/mL — what am I missing here

Question Clean Column ×7 Well Actually ×3

Right, the mg/mL question again, but with numbers this time.

I have 13 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 88, not week 42. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

8,817 up / 6,662 down57% upvoted48 commentsid 3rs69522 Mar 2026

48 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/janek_ferrari-34 points·4 months ago

dead space is real and the syringe matters

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u/a1c_arcT2D205 points·4 months ago

This is correct. 2mL versus 6mL is the common mistake.

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u/karl_fischer_kev50 points·4 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/ines_ekstromOP27 points·4 months ago

Reconstituted at 3mL when I meant 3mL. Caught it because the units looked wrong. Write the concentration.

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[removed]32 points·4 months ago

[removed by moderator]

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u/tuva_kirchner38 points·4 months ago

show your working or it is unhelpful

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u/a1c_arcT2D20 points·4 months ago

dead space is real and the syringe matters

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u/RetaAndRegret2127 points·4 months ago

What was the vial size and how much bac water?

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u/julia_erdogan62 points·4 months ago

u-100 syringe, not u-40, or your math is off by factor of 15

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u/india_generic_g91 points·4 months ago

What was the vial size and how much bac water?

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u/runa_cabrera32 points·4 months ago

Reconstituted at 2mL when I meant 7mL. Caught it because the units looked wrong. Write the concentration.

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u/ines_ekstromOP12 points·4 months ago

Reconstituted at 2mL when I meant 7mL.

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/viktor_kirchner111 points·4 months ago

show your working or it is unhelpful

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u/ilias_steiner55 points·4 months ago

show your working or it is unhelpful

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ahmed_rasmussen90 points·4 months ago·edited

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/karim_ilunga33 points·4 months ago·edited

Show the arithmetic. Where did the units come from?

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u/arne_restrepo39 points·4 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/oskar_ibarra27 points·4 months ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/ines_lindqvist52 points·4 months ago

Cored the stopper on my 16th draw because I kept using the same entry point. Rotate the puncture site.

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u/emil_wojcik36 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/ines_ekstromOP26 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/units_not_mgsyringe math37 points·4 months ago

u-100 syringe, not u-40, or your math is off by factor of 24

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u/tuva_kirchner7 points·4 months ago

dead space is real and the syringe matters

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u/soren_zamora6 points·4 months ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/bruno_dumitru34 points·4 months ago

the concentration on the vial in marker is the most important step

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u/emeka_delgado28 points·4 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/declared_value_dv16 points·4 months ago

never post a calculation as advice without stating the concentration

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u/yusuf_achebe9 points·4 months ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/swirl_dont_shakereconstitution8 points·4 months ago

dead space is real and the syringe matters

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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