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c/reconstitution·submitted 7 months ago by u/hedda_ekstrom

[Meta] the dead space rule is doing its job and people should stop complaining

Mathbranch of 9 comments

Genuinely asking, not being difficult. Everyone in c/cagrilintide repeats that dead space is important. I believe it, but I have never seen anyone show why, and when I search I get 7 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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9 comments, started 7 months ago
u/britta_nakamura83 points·7 months ago

Two vials, two different concentrations, forgot which was which, almost made a 9 times error. Now I label everything.

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u/honest_syringe_maybe22 points·7 months ago

stopper coring on the 20th draw because you keep using the same entry point. rotate.

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u/alcohol_aversion-22 points·7 months ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/ruben_cabrera9 points·7 months ago

stopper coring on the 20th draw because you keep using the same entry point.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/cesar_ivaturi54 points·7 months ago

Reconstituted at 2mL when I meant 13mL. Caught it because the units looked wrong. Write the concentration.

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u/rasmus_kuipers37 points·7 months ago

stopper coring on the 20th draw because you keep using the same entry point. rotate.

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u/quarter_dose_queenlow and slow27 points·7 months ago

5mg vial, 2mL water, concentration is 5/2 — write it on the vial afterwards

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u/priya_guerrero18 points·7 months ago

Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.

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u/piotr_bruun35 points·7 months ago

Two vials, two different concentrations, forgot which was which, almost made a 9 times error.

Adding to this: insulin syringe is doing more work than the comment implies.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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