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c/reconstitution·posted 8 months ago by u/quiet_reader_99

the Netherlands: dead space, and what it actually costs here

Question Clean Column ×3 Receipts ×2 Slow Clap ×1

Right, the units question again, but with numbers this time.

I have 21 data points over 20 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 81, not week 35. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

4,168 up / 464 down90% upvoted60 commentsid 8hi9jp27 Nov 2025

60 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/signe_grimaldi561 points·8 months ago

This is correct. 2mL versus 13mL is the common mistake.

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u/rasmus_mensah195 points·8 months ago

Mechanistically the bit that matters is bacteriostatic water. It explains most of the early profile and a decent chunk of the outcome.

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u/quiet_reader_99OP115 points·8 months ago

more water means more units for the same dose, which means finer resolution

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u/arto_falk241 points·8 months ago

never post a calculation as advice without stating the concentration

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u/vial_math_veraMOD295 points·8 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/anya_antonsen421 points·8 months ago·edited

the concentration on the vial in marker is the most important step

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[deleted]167 points·8 months ago

[deleted]

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u/dilara_szabo257 points·8 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/runa_grimaldi147 points·8 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/iman_falk82 points·8 months ago

never post a calculation as advice without stating the concentration

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u/lurker_for_years59 points·8 months ago

i am begging people to write down the concentration

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u/rina_bergstrom21 points·8 months ago

This is correct. 1mL versus 5mL is the common mistake.

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u/runa_cabrera152 points·8 months ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/quiet_reader_99OP66 points·8 months ago

Cored the stopper on my 12th draw because I kept using the same entry point. Rotate the puncture site.

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u/dexa_twice_yearlybody comp22 points·8 months ago

Cored the stopper on my 12th draw because I kept using the same entry point.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/honest_syringe_2025128 points·8 months ago

This is correct. 3mL versus 15mL is the common mistake.

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u/mateusz_achebe78 points·8 months ago

This is correct.

Adding to this: mg/mL is doing more work than the comment implies.

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u/bruno_dumitru83 points·8 months ago

never post a calculation as advice without stating the concentration

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u/ruben_cabrera51 points·8 months ago·edited

This is correct. 3mL versus 12mL is the common mistake.

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u/erez_perrin13 points·8 months ago

This is correct. 3mL versus 17mL is the common mistake.

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u/clara_weiss11 points·8 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/emeka_delgado60 points·8 months ago

This is correct. 1mL versus 8mL is the common mistake.

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u/clara_weiss40 points·8 months ago

dead space is real and the syringe matters

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u/emil_wojcik33 points·8 months ago

dead space is real and the syringe matters

Adding to this: dead space is doing more work than the comment implies.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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