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c/reconstitution·posted 2 years ago by u/elodie_grimaldi

help me understand reconstitution, I have read the wiki twice

Question Cold Box ×4

Been lurking in c/insurancefights for about 16 months and finally have something worth posting.

Short version: week 38, 0.5mg, and reconstitution is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 15 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 44.

490 up / 162 down75% upvoted27 commentsid g5jn1b5 Apr 2024

27 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/anya_antonsen56 points·2 years ago

Spent 21 weeks confused about concentration math until someone showed me the table. 15mg, 3mL, concentration is 15/3.

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u/signe_grimaldi44 points·2 years ago

dead space is real and the syringe matters

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[removed]32 points·2 years ago

[removed by moderator]

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u/dexa_twice_yearlybody comp31 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/anya_antonsen18 points·2 years ago·edited

the concentration on the vial in marker is the most important step

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u/ilias_cabrera21 points·2 years ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/anjali_tamm4 points·2 years ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/ilias_cabrera28 points·2 years ago

Dead space ate 13 units on a low-volume draw. Tiny impact at 7.5mg, massive impact at 2.4mg.

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u/tl_dr_tina9 points·2 years ago

Not convinced. The evidence does not support that reading.

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u/nabila_espinoza7 points·2 years ago

the concentration on the vial in marker is the most important step

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u/dilara_szabo6 points·2 years ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/britta_nakamura2 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/runa_cabrera2 points·2 years ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/ruben_cabrera2 points·2 years ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/yusuf_achebe1 point·2 years ago·edited

u-100 syringe, not u-40, or your math is off by factor of 24

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u/bac_water_banditMOD19 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/rasmus_kuipers5 points·2 years ago

dead space is real and the syringe matters

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u/elodie_grimaldiOP9 points·2 years ago

Reconstituted at 3mL when I meant 22mL. Caught it because the units looked wrong. Write the concentration.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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