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c/retatrutide·submitted 1 year ago by u/trialwatch_theo

dose escalation: the version I wish someone had shown me in week 1

Discussionbranch of 7 comments

Confession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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7 comments, started 1 year ago
u/jarno_cabrera317 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/incretin_ivypharmacology266 points·1 year ago

the 7.5mg arm is different from 0.25mg, results do not transfer

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u/emil_wojcik76 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/yusuf_ramos24 points·1 year ago·edited

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/careful_gradient_notes48 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/rekha_vestergaard26 points·1 year ago

triple agonism is phase 2, do not generalise

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u/kavya_kravchenko-32 points·1 year ago

No.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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