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c/retatrutide·submitted 10 months ago by u/incretin_ivy

[Question] triple agonist — what am I missing here

Questionbranch of 5 comments

Been lurking in c/sideeffects for about 7 months and finally have something worth posting. Short version: week 42, 15mg, and triple agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 19 threads, and the answers split roughly down the middle. What I actually want to…

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5 comments, started 10 months ago
u/kavya_kravchenko168 points·10 months ago

TRIUMPH phase 2 showed 99.3% weight loss but the nausea profile on the highest arm was rough. Phase 2 != phase 3.

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u/ledger_modMOD95 points·10 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[removed]37 points·10 months ago

[removed by moderator]

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u/incretin_ivyOPpharmacology72 points·10 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/helga_vermeulen45 points·10 months ago

triple agonism is phase 2, do not generalise

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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