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c/retatrutide·submitted 2 years ago by u/customs_seizure_sid

what changed for me between week 10 and week 59

Discussionbranch of 6 comments

Been lurking in c/progresspics for about 14 months and finally have something worth posting. Short version: week 15, 0.5mg, and TRIUMPH is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 37 threads, and the answers split roughly down the middle. What I actually want to know…

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6 comments, started 2 years ago
u/yusuf_ramos581 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/incretin_ivyMOD430 points·2 years ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/yannick_barros257 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/lurker_for_years167 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/customs_seizure_sidOP252 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/hassan_nilsen188 points·2 years ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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