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c/retatrutide·submitted 2 years ago by u/noor_ivaturi

switched from 1.0mg to 2.5mg and the fatigue got better, not worse

Cautionbranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against ApoB for 19 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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This branch

7 comments, started 2 years ago
u/farid_molnar208 points·2 years ago

This is correct. Triple agonism is genuinely different.

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u/noor_ivaturiOP155 points·2 years ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/anya_moreau38 points·2 years ago

I am going to push back on this slightly.

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u/rui_only_ro20 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/sofia_wikstrom5 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/noor_ivaturiOP85 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/nabila_bakken129 points·2 years ago

Dose escalation on retatrutide is steeper and faster than on semaglutide.

Yes, exactly this, and it is the bit that took me 4 weeks to accept.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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