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c/retatrutide·submitted 2 years ago by u/mateusz_mensah

[Discussion] the glucagon advice in here is 17 years out of date

Discussionbranch of 5 comments

Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse than the…

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5 comments, started 2 years ago
u/hugo_pires106 points·2 years ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/yannick_salinas150 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/janek_ferrari31 points·2 years ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/crosspost_bot_no25 points·2 years ago·edited

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/nikhil_asante14 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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