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c/retatrutide·submitted 1 year ago by u/careful_gradient_notes

anyone else notice retatrutide kicking in around week 94

Discussionbranch of 6 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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6 comments, started 1 year ago
u/quiet_moderatormod42 points·1 year ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/priya_weiss50 points·1 year ago

The glucagon component does different things than dual agonism. The injection-site soreness are not just amplified versions.

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u/viktor_laurent38 points·1 year ago

research use only, handling and analysis, not protocols

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u/farid_molnar10 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/crosspost_bot_no6 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/careful_gradient_notesOP2 points·1 year ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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