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Single comment threadYou are looking at one branch of phase 2 vs triple agonist — genuinely asking which matters more — 27 comments in the full submission. View in context.
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c/retatrutide·submitted 2 months ago by u/rohan_cardoso

phase 2 vs triple agonist — genuinely asking which matters more

Trial Databranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 31 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one…

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7 comments, started 2 months ago
u/trialwatch_theotrial nerd186 points·2 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/bilal_osei130 points·2 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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[deleted]48 points·2 months ago

[deleted]

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u/bilal_osei34 points·2 months ago

triple agonism is glucagon, do not generalise

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u/halima_mbeki20 points·2 months ago

nobody should be giving this to anyone without extensive monitoring

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u/rohan_cardosoOP117 points·2 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/yusuf_ramos42 points·2 months ago

the 0.5mg arm is different from 0.25mg, results do not transfer

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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