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c/retatrutide·submitted 3 months ago by u/lina_bruun

14 months in and dose escalation is still the thing I get wrong

Cautionbranch of 5 comments

I have had 12 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 4 days on nominally the same lane, which matters more in summer than in February. The independent number came back 96.8% against a claimed…

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5 comments, started 3 months ago
u/ismael_eriksen129 points·3 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/lina_bruunOP188 points·3 months ago

Water content matters more than people think.

Adding to this: triple agonist is doing more work than the comment implies.

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u/lina_bruunOP122 points·3 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/lina_bruunOP0 points·3 months ago

The glucagon component does different things than dual agonism. The constipation are not just amplified versions.

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u/hugo_pires1 point·3 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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