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c/retatrutide·submitted 6 months ago by u/andres_restrepo

[Discussion] can we stop arguing about glucagon until somebody posts a number

Discussionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 24 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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6 comments, started 6 months ago
u/tired_ledger_notes406 points·6 months ago·edited

What was the dosing schedule in that arm?

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u/andres_restrepoOP215 points·6 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/bilal_osei251 points·6 months ago

the glucagon component changes the side effect profile, not just the efficacy

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u/iman_castellanos165 points·6 months ago

the glucagon component changes the side effect profile, not just the efficacy

Yes, exactly this, and it is the bit that took me 5 weeks to accept.

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u/titration_marshalmod · c/semaglutide-8 points·6 months ago

Are you quoting phase 2 or is there phase 3 data now?

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u/nikhil_asante1 point·6 months ago

nobody should be giving this to anyone without extensive monitoring

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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