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c/semaglutide·posted 9 months ago by u/arne_restrepo

reading Wegovy threads from 2024 and half of it aged badly

Question Cold Box ×3

Posting this because I searched for it and got nothing useful.

Setup: 0.25mg, week 64, constipation present but not ruining anything. I changed exactly one variable — Ozempic — and tracked it for 16 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

801 up / 308 down72% upvoted27 commentsid h0sp5m3 Oct 2025

27 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/source_or_silence79 points·9 months ago

Maintenance for 11 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/arne_restrepoOP93 points·9 months ago

My early fullness was worst at 2.5mg and better at 2.4mg, which makes no sense and I have stopped trying to explain it.

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u/ines_castellanos30 points·9 months ago

week 96 on the pen, 29kg down, this is the answer

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u/dose_creep_dan21 points·9 months ago

Yeah, 19 weeks on 5mg, same pattern, same timing.

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u/ferritin_low69 points·9 months ago

My early fullness was worst at 2.5mg and better at 2.4mg, which makes no sense and I have stopped trying to explain it.

Disagree on that part. 99.0% and 98.9% on the same vial is normal.

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u/rina_bergstrom48 points·9 months ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/titration_marshalMOD52 points·9 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/arne_restrepoOP0 points·9 months ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/stubborn_batchlist_only1 point·9 months ago

stalled at 12.5mg, went up, and regretted it, the stall would have broken anyway

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u/iman_castellanos1 point·9 months ago

stalled at 12.5mg, went up, and regretted it, the stall would have broken anyway

Yes, exactly this, and it is the bit that took me 72 weeks to accept.

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u/teodor_duarte1 point·9 months ago

Not to be pedantic but semaglutide and titration are being used interchangeably and they are not interchangeable in real life.

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u/quiet_moderatormod0 points·9 months ago

okay but what dose of sema are you on

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[removed]25 points·9 months ago

[removed by moderator]

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u/arne_restrepoOP39 points·9 months ago

I did the fast version. 10mg to 0.25mg in 24 weeks. Spent a weekend learning why the schedule exists.

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u/lane_map_larrylogistics13 points·9 months ago

I did the fast version.

Adding to this: titration is doing more work than the comment implies.

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u/wanjiru_varga19 points·9 months ago

the quiet is real. the food noise just stops.

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u/dead_space_doug25 points·9 months ago
this is the answer
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u/oskar_kaufmann16 points·9 months ago·edited

Strongly agree. If it is not working at 0.5mg after 89 weeks, going up is not automatically the answer.

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u/careful_gradient_again8 points·9 months ago

my ferritin moved before the scale did and i nearly missed it

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