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c/sideeffects·posted 3 days ago by u/nausea_notes· stickied

nausea day 2 post-injection like clockwork, week 14, does it ever stop

Side Effects

Fourteen months of logging this. Pattern is boringly consistent: injection evening fine, day 1 fine, day 2 rough from about mid-morning to bedtime, day 3 onwards fine.

It has got milder over time but it has not gone. Every dose step resets it to about where it was at the start, then it fades over three or four weeks.

Question for people further along than me: does the day-2 pattern eventually disappear, or does it just become background?

102 up / 34 down75% upvoted14 commentsid 188gzo27 Jul 2026

14 comments

14 in this archive, depth 6

best — the order this archive was captured in

u/maintenance_mode_maxmaintenance289 points·2 days ago

Nineteen months at maintenance. Mine became background and then stopped being noticeable, but the honest answer is that I cannot tell you whether it went away or whether I stopped noticing it. Those feel the same from the inside.

What definitely changed: no dose steps means no resets. Most of what you are describing is escalation, not the drug.

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u/nausea_notesOPside effects154 points·2 days ago

"most of what you are describing is escalation" reframes fourteen months of my own log in one sentence. every reset was a step.

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u/gastric_emptying_g132 points·1 days ago

Which fits the mechanism. The GI effects track the change in gastric emptying rather than the absolute level, so a new dose produces a new adaptation period. Once you stop changing the input the system settles.

Day 2 specifically is roughly where the concentration peaks after a subcutaneous dose, which is why the timing is so reproducible for so many people.

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u/nightowl_injector104 points·1 days ago

and this is why moving to friday evening works. it does not reduce anything, it just moves day 2 onto a saturday.

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u/vomit_free_since88 points·1 days ago

the thing that actually reduced it for me was stopping at 70% full. not a supplement, not timing, just eating less at once on day 2.

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u/nausea_notesOPside effects96 points·1 days ago

i have tried about nine things and that is the only one that survived contact with my own log. ginger did nothing.

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u/titration_marshalMOD143 points·2 days ago

Good post. Reminder for the thread: dose, week number and titration speed in the body or nobody can help. This post has all three, which is why the replies are useful.

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u/sulphur_burps_sue118 points·2 days ago

my day-2 came with the sulphur burps and i want it on record that those are worse than the nausea and pass just as reliably.

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u/reflux_report88 points·2 days ago

mine got worse for three weeks then better than baseline. the "worse before better" shape catches people out because it looks like deterioration.

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u/hydration_hank96 points·2 days ago

half the day-2 reports i read are dehydration wearing a costume. not all. half.

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u/nausea_notesOPside effects71 points·2 days ago·edited

tracked fluid intake for six weeks specifically to test this. no correlation in my data. edit: which is one person, and hank is right often enough that it is worth checking.

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u/downvote_magnet-12 points·3 days ago

if you still have nausea at week 14 you are on too high a dose

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u/titration_marshalMOD132 points·3 days ago

That is a dose recommendation for an individual and it is removed everywhere on this site. Leaving it visible with this reply because the pattern is worth seeing rather than hiding.

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[removed]-6 points·2 days ago

[removed by moderator]

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