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c/tapering·posted 4 months ago by u/chidi_vermeulen

Germany: discontinuation, and what it actually costs here

Regain

Posting this because I searched for it and got nothing useful.

Setup: 0.5mg, week 89, injection-site soreness present but not ruining anything. I changed exactly one variable — discontinuation — and tracked it for 18 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

177 up / 52 down77% upvoted21 commentsid 1jbtc78 Mar 2026

21 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/neha_krastev29 points·4 months ago

regain on taper is expected, plan for it

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u/zeynep_villalobos18 points·4 months ago

regain on taper is expected, plan for it

Yes, exactly this, and it is the bit that took me 4 weeks to accept.

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u/chidi_vermeulenOP12 points·4 months ago·edited

regain on taper is expected, plan for it Yes, exactly this, and it is the bit that took me 4 weeks to accept.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/appeal_letter_al-33 points·4 months ago

Strongly agree. The regain is expected.

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u/neha_mwangi34 points·4 months ago

appetite return timelines vary regain

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u/arne_restrepo26 points·4 months ago

regain on taper is expected, plan for it

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u/ferran_krastev14 points·4 months ago

What are you comparing it against though?

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u/maintenance_mode_maxmaintenance7 points·4 months ago

coming off deliberately, not by accident

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u/diego_szabo15 points·4 months ago

Mechanistically the bit that matters is regain. It explains most of the early profile and a decent chunk of the outcome.

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u/chidi_vermeulenOP6 points·4 months ago

Mechanistically the bit that matters is regain.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/zeynep_weiss9 points·4 months ago

no shaming people who restart

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u/rekha_teixeira3 points·4 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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