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c/tapering·submitted 4 months ago by u/chidi_vermeulen

Germany: discontinuation, and what it actually costs here

Regainbranch of 4 comments

Posting this because I searched for it and got nothing useful. Setup: 0.5mg, week 89, injection-site soreness present but not ruining anything. I changed exactly one variable — discontinuation — and tracked it for 18 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else…

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4 comments, started 4 months ago
u/diego_szabo15 points·4 months ago

Mechanistically the bit that matters is regain. It explains most of the early profile and a decent chunk of the outcome.

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u/chidi_vermeulenOP6 points·4 months ago

Mechanistically the bit that matters is regain.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/zeynep_weiss9 points·4 months ago

no shaming people who restart

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u/rekha_teixeira3 points·4 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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