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c/tapering·posted 4 months ago by u/injection_site_iris

interval stretching is the most under-discussed thing in c/compounding

Regain Cold Box ×3 Slow Clap ×1

Right, the tapering question again, but with numbers this time.

I have 15 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 59, not week 13. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

2,067 up / 778 down73% upvoted62 commentsid 1jlsxw19 Mar 2026

62 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/honest_syringe_2025-25 points·4 months ago

Strongly agree. The regain is expected.

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u/taper_off_tabitha1 point·4 months ago

Small correction: the trial was 8 weeks, not 26. Does not change your point but people will quote it.

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u/meera_oyelaran76 points·4 months ago

the regain is treatment of chronic condition ending, not failure

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u/maintenance_mode_maxMOD40 points·4 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/priya_guerrero17 points·4 months ago

Removed a chain here.

Yes, exactly this, and it is the bit that took me 69 weeks to accept.

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u/meera_oyelaran11 points·4 months ago

no shaming people who restart

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u/customs_seizure_sid69 points·4 months ago

This is correct. Discontinuation data is real.

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u/nayeli_fonseca19 points·4 months ago

Small correction: the trial was 16 weeks, not 14. Does not change your point but people will quote it.

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u/farid_kuipers0 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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[removed]13 points·4 months ago

[removed by moderator]

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u/rafael_sjoberg31 points·4 months ago

no shaming people who restart

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u/injection_site_irisOP23 points·4 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/andres_restrepo11 points·4 months ago

Disagree. What you are describing is consistent with tapering, not with what you concluded.

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u/nora_ramos4 points·4 months ago·edited

the 7 week discontinuation arm is the data

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u/valeria_girard18 points·4 months ago

Strongly agree. The regain is expected.

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u/adaeze_brandt11 points·4 months ago

coming off deliberately, not by accident

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u/vikram_ferreira37 points·4 months ago

This is correct. Discontinuation data is real.

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u/injection_site_irisOP29 points·4 months ago·edited

Stalled for 19 weeks, changed nothing, and it started moving again on week 92.

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u/nora_ramos30 points·4 months ago·edited

the regain is treatment of chronic condition ending, not failure

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u/nabila_bakken13 points·4 months ago

the people who came off and restarted without shame

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u/ilias_kaufmann23 points·4 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/dario_stanescu19 points·4 months ago

Week 32 for me and the honest summary is: 21kg down, injection-site soreness manageable, and I have thought about food maybe four times today.

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u/piotr_bruun10 points·4 months ago

interval stretching versus dose reduction

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u/ahmed_okafor16 points·4 months ago
i do not know. that is the honest answer.
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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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