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c/tapering·submitted 4 months ago by u/injection_site_iris

interval stretching is the most under-discussed thing in c/compounding

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Right, the tapering question again, but with numbers this time. I have 15 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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10 comments, started 4 months ago
u/customs_seizure_sid69 points·4 months ago

This is correct. Discontinuation data is real.

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u/nayeli_fonseca19 points·4 months ago

Small correction: the trial was 16 weeks, not 14. Does not change your point but people will quote it.

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u/farid_kuipers0 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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[removed]13 points·4 months ago

[removed by moderator]

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u/rafael_sjoberg31 points·4 months ago

no shaming people who restart

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u/injection_site_irisOP23 points·4 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/andres_restrepo11 points·4 months ago

Disagree. What you are describing is consistent with tapering, not with what you concluded.

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u/nora_ramos4 points·4 months ago·edited

the 7 week discontinuation arm is the data

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u/valeria_girard18 points·4 months ago

Strongly agree. The regain is expected.

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u/adaeze_brandt11 points·4 months ago

coming off deliberately, not by accident

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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