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[Discussion] we are measuring discontinuation at the wrong time and calling it noise
appetite return. That is the whole post, but I will justify it. Everything else people worry about in c/glp1eu is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort appetite return out first, and almost nobody does. I say this having got it wrong for 21 months. My…
the people who came off and restarted without shame
the people who came off and restarted without shame
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
interval stretching versus dose reduction
Strongly agree. The regain is expected.
cite the discontinuation data rather than guessing regain rates
This is correct. Discontinuation data is real.