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c/tapering·posted 8 months ago by u/yara_lindholm

[Question] discontinuation — what am I missing here

Question

Trying to settle this properly because the thread from last year went in circles.

The claim: regain matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything.

What would actually settle it is 9 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

317 up / 119 down73% upvoted16 commentsid if71g817 Nov 2025

16 comments

16 in this archive, depth 3

best — the order this archive was captured in

u/skip_week_scepticMOD24 points·8 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/ignacio_silva7 points·8 months ago

Strongly agree. The regain is expected.

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u/yara_lindholmOP12 points·8 months ago

Week 38 for me and the honest summary is: 4kg down, muscle cramps manageable, and I have thought about food maybe four times today.

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[removed]6 points·8 months ago

[removed by moderator]

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u/aleksi_lehtinen11 points·8 months ago

Strongly agree. The regain is expected.

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u/cormac_erdogan3 points·8 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/britta_boateng11 points·8 months ago

interval stretching versus dose reduction

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u/rekha_teixeira5 points·8 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/zeynep_villalobos2 points·8 months ago

cite the discontinuation data rather than guessing regain rates

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u/andres_restrepo7 points·8 months ago·edited

Stalled for 19 weeks, changed nothing, and it started moving again on week 62.

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u/yara_lindholmOP3 points·8 months ago

Stalled for 19 weeks, changed nothing, and it started moving again on week 62.

Yes, exactly this, and it is the bit that took me 28 weeks to accept.

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u/maren_baptista7 points·8 months ago

Respectfully this is a sample of one presented as a finding.

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u/rafael_sjoberg6 points·8 months ago
^ this
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u/fabio_lehtinen5 points·8 months ago·edited

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/neha_mwangi3 points·8 months ago

Not to be pedantic but interval stretching and appetite return are being used interchangeably and they are not interchangeable in real life.

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u/ahmed_okafor2 points·8 months ago

That is net peptide content, not purity. Different number, different meaning.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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