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c/tapering·posted 8 months ago by u/zeynep_weiss

the Netherlands: discontinuation, and what it actually costs here

Trial Data

Week 58 update. 19kg down from the start, early fullness basically gone since about week 3.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

128 up / 6 down96% upvoted19 commentsid ip6n572 Nov 2025

19 comments

15 in this archive, depth 3

best — the order this archive was captured in

u/maren_baptista24 points·8 months ago

cite the discontinuation data rather than guessing regain rates

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u/zeynep_weissOP19 points·8 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/meera_oyelaran15 points·8 months ago·edited

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/naomi_ekstrom16 points·8 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/zeynep_weissOP7 points·8 months ago

the regain is treatment of chronic condition ending, not failure

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u/yara_bakken11 points·8 months ago
source?
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u/taper_off_tabithaMOD9 points·8 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/border_paperwork2 points·8 months ago

the 14 week discontinuation arm is the data

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u/cormac_roos1 point·8 months ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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[removed]1 point·8 months ago

[removed by moderator]

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u/katrin_diallo3 points·8 months ago

coming off deliberately, not by accident

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u/preservative_free_p4 points·8 months ago

appetite return timelines vary regain

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u/skip_week_sceptic1 point·8 months ago

say how long you were on and at what dose before taper

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u/priya_weiss1 point·8 months ago

interval stretching versus dose reduction

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u/chidi_vermeulen1 point·8 months ago·edited

the regain is treatment of chronic condition ending, not failure

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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