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c/tirzepatide·submitted 2 years ago by u/kaia_wojcik

[Lab] 13th independent test on BCH, and the trend is the interesting part

Labbranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking tirzepatide against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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9 comments, started 2 years ago
u/ghrp_history313 points·2 years ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/zeynep_zielinski147 points·2 years ago

Hard agree. The food noise disappears differently on the two compounds.

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u/noor_hovland118 points·2 years ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/spain_receta52 points·2 years ago

week 14 on Mounjaro and the appetite profile is genuinely different from sema

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u/ewan_marchand21 points·2 years ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/dario_vermeulen62 points·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/nz_unfunded114 points·2 years ago

Hard agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/zaid_balogun178 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/titration_marshalmod · c/semaglutide44 points·2 years ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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