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c/tirzepatide·submitted 2 years ago by u/zeynep_ndiaye

anyone else notice Zepbound kicking in around week 54

Labbranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 0.5mg, week 93, injection-site soreness present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 17 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted…

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8 comments, started 2 years ago
u/zeynep_zielinski93 points·2 years ago
more of this energy please
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[removed]38 points·2 years ago

[removed by moderator]

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u/rania_diallo27 points·2 years ago

the early fullness from tirz is different, not necessarily worse

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u/zeynep_ndiayeOP47 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/vito_chowdhury68 points·2 years ago

week 11 on Mounjaro and the appetite profile is genuinely different from sema

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u/elin_varga24 points·2 years ago

the 15mg is the top of the pen, not the required dose

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u/taper_off_tabitha32 points·2 years ago

dual agonism is Zepbound, do not generalise from semaglutide

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u/teodor_szabo28 points·2 years ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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