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c/tirzepatide·submitted 2 years ago by u/taper_off_tabitha

three years of Mounjaro threads, summarised so you do not have to read them

Discussionbranch of 10 comments

Confession thread, sort of. I went from 5mg to 1.7mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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10 comments, started 2 years ago
u/certified_referenceQC129 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/line_petrov32 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/search_before_post108 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/thyroid_tangent127 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

Yes, exactly this, and it is the bit that took me 67 weeks to accept.

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u/taper_off_tabithaOP57 points·2 years ago

My hs-CRP moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/customs_seizure_sid74 points·2 years ago

the reflux from tirz is different, not necessarily worse

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u/taper_off_tabithaOP66 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes

Yes, exactly this, and it is the bit that took me 72 weeks to accept.

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u/gentle_correctionnice about it16 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes Yes, exactly this, and it is the bit that took me 72 weeks to accept.

Yes, exactly this, and it is the bit that took me 53 weeks to accept.

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u/taper_off_tabithaOP28 points·2 years ago

do not crack the pen, we have been over this

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u/samir_falk50 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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