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c/tirzepatide·submitted 2 years ago by u/tove_vasquez

[Results] 57 weeks, 20kg, and tirzepatide was the hard part

Resultsbranch of 8 comments

Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…

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8 comments, started 2 years ago
u/alcohol_aversion263 points·2 years ago

This matches the trial data. SURMOUNT-1 was 99.2% body weight at 20 weeks.

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u/ignacio_vanhecke183 points·2 years ago

How long at each step before you escalated?

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u/alcohol_aversion75 points·2 years ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/throwaway_titration45 points·2 years ago

How long at each step before you escalated?

Yes, exactly this, and it is the bit that took me 68 weeks to accept.

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u/b12_baseline16 points·2 years ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/teodor_szabo299 points·2 years ago·edited

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

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u/tove_vasquezOP170 points·2 years ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/piotr_nascimento66 points·2 years ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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