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c/tirzepatide·submitted 2 years ago by u/alcohol_aversion

small win: dual agonist stopped being a problem at week 66

Discussionbranch of 4 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 14 months without either producing anything. What would actually settle it is 23 people measuring the…

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4 comments, started 2 years ago
u/coring_the_stopper146 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/hair_shed_hannah109 points·2 years ago

the 15mg is the top of the pen, not the required dose

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u/slow_logbook_ftw71 points·2 years ago

the 15mg is the top of the pen, not the required dose

Adding to this: GIP is doing more work than the comment implies.

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u/alcohol_aversionOP47 points·2 years ago·edited

week 13 on Mounjaro and the appetite profile is genuinely different from sema

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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