small win: dual agonist stopped being a problem at week 66
Trying to settle this properly because the thread from last year went in circles.
The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 14 months without either producing anything.
What would actually settle it is 23 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Retitled to remove editorialising. Put the evidence in the body.
My fasting insulin moved faster on tirz than on sema at the same timepoint, which matches what people report.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
Not convinced. The evidence does not support that reading.
Is that on Mounjaro pens or research tirzepatide?
The confident tone is doing a lot of work that the evidence is not.
the 15mg is the top of the pen, not the required dose
the 15mg is the top of the pen, not the required dose
Adding to this: GIP is doing more work than the comment implies.
week 13 on Mounjaro and the appetite profile is genuinely different from sema
This matches the trial data. SURMOUNT-1 was 93.7% body weight at 4 weeks.
the dual agonism hits different and that is why people describe it differently
the GIP side does different things than the GLP-1 side, that is the point
Slight fix: the number was 98.0, not 98.1. Decimal point, but a fairly consequential one.
This matches the trial data.
Yes, exactly this, and it is the bit that took me 13 weeks to accept.
- 1This matches the trial data. SURMOUNT-1 was 93.7% body weight at 4 weeks.5 comments in this branch · started by u/quiet_moderator
- 2The confident tone is doing a lot of work that the evidence is not.4 comments in this branch · started by u/coring_the_stopper